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October 15-16, 2025  |  Crowne Plaza Union Station

ABOUT

The Midwest Defense Innovation Summit is the region’s premier gathering for advancing national security through cutting-edge innovation. Powered by the Applied Research Institute, this high-impact summit convenes policymakers, industry leaders, defense stakeholders, and regional partners to explore the latest advancements and emerging opportunities in artificial intelligence and beyond.

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MDIS 2025 will take place October 15–16, 2025, at the Grand Hall Ballroom at Crowne Plaza Union Station, located in the heart of downtown Indianapolis.

WHO

This year’s summit will feature a series of keynote addresses and panel discussions, focused on the transformative role of artificial intelligence. 

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Our full speaker lineup and session details will be announced soon - stay tuned for an agenda designed to inform, inspire, and drive impact.

WHY

Stay Ahead of the Curve: Gain insight into the latest trends, technologies, and policy developments shaping the future of defense and national security.

Collaborate and Innovate: Engage with top minds across government, industry, and academia to spark partnerships and accelerate solutions.

Shape the Future: Be part of the critical conversations that will define the next era of American defense and innovation.

REGISTRATION

Every attendee must have their own registration; if attending in group, each member will need to register. Please note: there will be no onsite registration available.

Register
SPEAKERS & PANELS

We’ve secured an exceptional roster of speakers - leaders and innovators from across the defense, technology, and policy sectors who will bring powerful insights to the summit.
 

Final programming details are underway and will be announced shortly. This page will be updated with the full agenda and speaker lineup. 

Announcing Soon

AGENDA

To view the most up-to-date version of the agenda, event schedule and session details, click the button below. 

Announcing Soon

SPONSORS

Don’t miss the opportunity to be a part of the 2025 Midwest Defense Innovation Summit. We look forward to partnering with you to make this event a success.

Apply to learn more about 2025 sponsorship opportunities or view the PDF below! 

VENUE

Crowne Plaza Union Station
123 W Louisiana Street, Indianapolis, IN 46225 â€‹

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Hotels

HOTELS

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Crowne Plaza Indianapolis Downtown Union Station

123 W Louisiana St

Indianapolis, IN 46225

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Holiday Inn Indianapolis Downtown

515 S West St

Indianapolis, IN 46225

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Indianapolis Marriott Downtown

250 W Maryland St

Indianapolis 46225

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Hilton Indianapolis Hotel & Suites

120 West Market St

Indianapolis, IN 46204

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