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From the Midwest to the Mission: Advancing National Security from America’s Heartland

April 8-9, 2026

Grand Hall - Crowne Plaza Downtown Indianapolis Union Station

123 W Louisiana St, Indianapolis, IN

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Doors open 08:00

BACKGROUND

The Midwest Defense Innovation Summit (MDIS) is the region’s premier gathering focused on advancing national security through mission-driven technology and capability development. Powered by the Applied Research Institute, this high-impact summit convenes senior defense leaders, policymakers, industry, academia, and regional partners to examine how emerging technologies are tested, transitioned, and fielded at speed in support of national defense priorities. MDIS emphasizes operational relevance, strategic competition, and the pathways that move innovation from concept to deployed capability.

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MDIS is now rescheduled to April 8-9, 2026, at the Grand Hall Ballroom at Crowne Plaza Union Station, located in the heart of downtown Indianapolis. Registration is now OPEN! Secure your spot below with a ticket to attend this year’s summit. 

WHAT TO EXPECT

This year’s summit will feature keynote addresses, fireside conversations, and panel discussions led by the leaders shaping the future of defense—firmly rooted in America’s Heartland.

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Our full speaker lineup and session details will be announced soon - stay tuned for an agenda designed to inform, inspire, and drive impact.

STAY INFORMED

Stay informed on all the latest announcements, agenda updates, and breakout sessions. Click the button below to join our email list, or follow us on all our social platforms for the most up to date information.

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REGISTRATION

Two days, one ticket. Every attendee must have their own registration; if attending in group, each member will need to register. Please note: there will be no onsite registration available.

Event Date: April 8th-9th, 2026

Event Location: Crowne Plaza Downtown Indianapolis Union Station | 123 W Louisiana St, Indianapolis, IN

Room: Grand Hall

WELCOME RECEPTION

Open for all ticketed MDIS Attendees! Join us for an engaging welcome reception designed to bring together industry leaders, speakers, and exhibitors in a relaxed, high-energy setting. This is your first opportunity to connect with fellow attendees, spark meaningful conversations, and begin building valuable relationships ahead of the main event. Enjoy a curated selection of hors d'oeuvres and alcoholic beverages as you explore the space, meet our exhibitors, and network with peers from across the industry. Whether you're reconnecting with colleagues or making new introductions, the welcome reception sets the tone for the anticipated discussions set to take place over the next two days. We encourage you to take advantage of this time to build connections and kick off your event experience.

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Location: Grand Hall Union Station – Pre-Function Space | 123 W Louisiana St, Indianapolis, IN

Date: Tuesday, April 7, 2026

Time: 5:30 pm – 7:30 pm

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Please update your registration to let us know if your plans have changed! 

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Register

SPEAKERS & PANELS

We’re excited to introduce an outstanding lineup of speakers for the Midwest Defense Innovation Summit (MDIS) 2026 happening April 8-9, 2026 at the Crowne Plaza Union Station in Indianapolis. This powerhouse group includes pioneers in defense, leadership, academia,  government and more, ready to deliver game-changing insights on the future of national security.
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Join us to connect with these thought leaders and shape the future of defense innovation. 

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